C277
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C277
Sigma
Chloro-IB-MECA
solid, ≥98% (HPLC)
| Synonym: | Cl-IB-MECA, 2-Chloro-N6-(3-iodobenzyl)-adenosine-5′-N-methyluronamide |
| CAS Number: | 163042-96-4 |
| Linear Formula: | C18H18ClIN6O4 |
| Molecular Weight: | 544.73 |
| MDL number: | MFCD01323055 |
| PubChem Substance ID: | 24278354 |
Description
| Biochem/physiol Actions | A3 adenosine receptor agonist. |
Properties
| assay | ≥98% (HPLC) |
| form | solid |
| color | white |
| solubility | DMSO: >20 mg/mL |
| Gene Information | human ... ADORA1(134), ADORA2A(135), ADORA2B(136), ADORA3(140) |
| rat ... Adora1(29290), Adora2a(25369), Adora3(25370) |
Safety
| Personal Protective Equipment | dust mask type N95 (US), Eyeshields, Gloves |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36 |
| WGK Germany | 3 |
References
| reference | Dunwiddie, T.V., et al., Activation of hippocampal adenosine A3 receptors produces a desensitization of A1 receptor-mediated responses in rat hippocampus. J. Neurosci. 17, 607-614, (1997) Abstract |
| Yao, Y., et al., Adenosine A3 receptor agonists protect HL-60 and U-937 cells from apoptosis induced by A3 antagonists. Biochem. Biophys. Res. Commun. 232, 317, (1997) Abstract | |
| Stambaugh, K., et al., A novel cardioprotective function of adenosine A1 and A3 receptors during prolonged simulated ischemia. Am. J. Physiol. 273, H501-H505, (1997) Abstract |
